Since the 1970s, UMB has been engaged in important public health initiatives around the world. In September 2009, the Maryland Global Initiatives Corporation (MGIC) was formed as a nonprofit affiliate of UMB to support the implementation of UMB's international programs.

MGIC establishes UMB-approved affiliates, known as “country offices,” when UMB’s international programs require them.  MGIC has previously operated as a registered business entity in Botswana, Haiti, Kenya, Malawi, Mozambique, Nigeria, Rwanda, Tanzania, and Uganda. MGIC has also registered to do business in the Democratic Republic of the Congo and Myanmar. Currently, MGIC operates a country office in Zambia.

International Operations administers MGIC on behalf of UMB and activates the use of MGIC when appropriate for any department or unit to safely and effectively implement international activities on behalf of UMB.