Research continues on many fronts to better understand the causes of various, and often overlapping, pain conditions. It is with greater understanding that we expect to identify alternative treatment approaches that improve the lives of people suffering with unremitting pain. Currently, several research studies are being conducted at CACPR.

facial photo

Studies on Chemotherapy-Induced Neuropathy

Would you be interested in participating in a research study? The University of Maryland is looking for participants for studies which examine brain function changes after chemotherapy (SONIC Study), and how portable brain imaging can be used to study the role of the brain in chemotherapy-induced neuropathy (LANTERN Study). For more information, please visit: https://www.nursing.umaryland.edu/research/mindbodycancer.

You might be eligible for the LANTERN study if:

  1. You are a woman (biological sex)
  2. You had a recent diagnosis of breast cancer
  3. You received taxane-based chemotherapy within the past 6 weeks
  4. You can read English
  5. You are at least 18 years old

Study involves 1 visit to University of Maryland, Baltimore for 3-4 hours and consists of:

  1. Questionnaires
  2. Symptom testing (finger sensations, heartbeats)
  3. Fitness testing (walking, hand grip)
  4. OPTIONAL Brain MRI scan (no radiation or injected contrast agents)

We offer up to $350 and free parking and transportation to and from our lab

American Cancer Society on a blue background with medical staffPlease contact us to learn more

Funded by the American Cancer Society (ACS) RSG-24-1308474-01-CPHP

 

What would I do as a study participant in the SONIC Study:

  1. You have breast or gastrointestinal cancer
  2. You will be starting chemotherapy or have just started (1-2 infusions)
  3. You do not have numbness, tingling, or burning pain in your hands or feet
  4. You are safe and comfortable with brain MRI (no radiation or injected contrast agents)
  5. You are at least 18 years old
  6. You can converse in English
  7. You have not had a brain injury in the past year

Study involves 3 visits over about 9 months to University of Maryland, Baltimore for 5 hours per visit, and consists of:

  1. Questionnaires
  2. Fasted blood draw
  3. Symptom testing (finger sensations, heartbeats)
  4. Fitness testing (walking, hand grip)
  5. Brain MRI scan (no radiation or injected contrast agents)

We offer up to $900 and free parking and transportation to and from our lab.

National Cancer Institute with NIH logoPlease contact us to learn more

Funded by the National Cancer Institute (NCI) grant R01CA278939

Healthy Participants Needed Research Study: Virtual Reality and Pain in the Brain

Study on the Effects of Nutrient Timing on Cancer-related Fatigue

This study examines the effects of a nutritional program with vs. without a time component to address cancer-related fatigue among blood cancer survivors (TAKE THE REINS Study).

You might be eligible for the TAKE THE REINS study if:

  • You are a blood cancer survivor
  • You were treated at one of the cancer centers in the University of Maryland hospital network
  • Are at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, CAR-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for >2 months and expected to stay on it until progression is okay
  • You have a baseline level of fatigue
  • You are able to speak and/or read and write in English or Spanish
  • You are at least 18 years old
  • Please see clinicaltrials.gov for full criteria.

The study can be completed remotely, lasts approximately 14 weeks with a follow-up at 24 weeks, and consists of:

  1. Online questionnaires related to your symptoms and feelings.
  2. Logging diet and sleep using a smartphone app and activity tracker for one week
  3. Tracking glucose levels via a continuous glucose monitor for one week
  4. Meeting with a nutritionist to discuss nutrition in cancer survivorship
  5. Following a food intake schedule for twelve weeks

We offer up to $100

Please contact us to learn more:

National Cancer Institute with NIH logoFunded by the National Cancer Institute (NCI) grant R01CA284082

Research Study: Pain Perception in the Brain

Study on Vasopressin and Pain perception in the Brain

This study uses fMRI to investigate how vasopressin influences the neural mechanisms associated with observationally-induced analgesia.

You might be eligible for the VASOPRESSIN study if:

  • You are in good health
  • You are 18 – 55 years of age
  • You are fluent in written and spoken English

The study consists of two sessions, and involves:

  1. Participating in a pain sensitivity assessment and competing a psychological questionnaire on day 1
  2. Completing an fMRI scan on day 2

We offer $25 for the first session and $125 for the second session, plus free parking

Please contact us to learn more:

  • Gabriella Thomas
  • Call: 410-706-5975
  • thomas@umaryland.edu
CACPR Placeholder

Study on Virtual Reality in the Treatment of Opioid Use Disorder

This study examines the efficacy of a virtual reality environment in modulating mood in people experiencing opioid use disorder and chronic pain (CARES VRinOUD Study).

You might be eligible for the CARES VRinOUD study if:

  • You are able to speak and read English
  • You are 18 – 65 years of age
  • You are enrolled in treatment and considered stabilized on MOUD by your provider within the past 3 months
  • You are able to access email

The study lasts approximately 5 weeks and involves:

  1. Questionnaires before and after treatment sessions
  2. Immersive Virtual Reality sessions after each in person counselling session
  3. Short daily surveys through Ecological Momentary Assessment (EMA)

We offer $250 (electronic gift cards) for completing the study, including up to 5 in-person clinic visits ($50), plus free parking

Please contact us to learn more:

  • Gabriella Thomas
  • Call: 410-706-5975
  • thomas@umaryland.edu
CACPR Placeholder

Study of Peak Alpha Frequency as a Biomarker for Persistent Post-Traumatic Headache

This study aims to identify EEG- and MRI-based biomarkers that predict the risk of developing persistent headache following a head injury, (PEAK ALPHA FREQUENCY Study).

You might be eligible for the PEAK ALPHA FREQUENCY study if:

  • You are 18 – 60 years of age
  • You have sustained a head injury or concussion within the past week

The study involves:

  1. Completing an EEG recording and questionnaires within 3 weeks of the head injury
  2. A second visit at three months for repeat EEG and MRI scans

We offer $75 for the first visit and $200 for the second visit

Please contact us to learn more:

or:

This study is sponsored by an Accelerated Translational Incubator Pilot (ATIP) Grant from UMB

CACPR Placeholder

Study of the Impact of Open-Label Placebo on Sleep and Pain Modulation

This study tests whether open-label placebo pills (known to contain no active medication) can reduce chronic pain and improve sleep quality over a 49-day period, (OPEN-LABEL PLACEBO Study).

You might be eligible for the OPEN-LABEL PLACEBO study if:

  • You are at least18 years of age
  • You have a confirmed diagnosis of temporomandibular disorders (TMD) and chronic pain
  • You are able to complete in-person visits, at-home sleep monitoring, and daily surveys.

This is a 49-day study that involves:

  • Four in-person visits, each lasting 1-2 hours

We offer up to $350, plus free parking

Please contact us to learn more:

This study is sponsored by the University of Maryland School of Nursing