Todd Gould, MD
Professor, Department of Psychiatry
SCHOOL OF MEDICINE
Research Interests
- Behavioral Pharmacology
Research Approaches
- Emotional aspects of chronic pain
Publications
- Brown KA, Morris PJ, Thomas CJ, Gould TD (2026) A time-sensitive plasticity distinguishes the rapid and sustained synaptic actions of ketamine from its (2R,6R)-hydroxynorketamine metabolite. Journal of Neuroscience.
- Brown KA, Ajibola MI, Medeiros GC, Gould TD (2025) Synaptic priming: a framework for pharmacotherapy in depression. Neuron. 113, 3722-3740.
- Riggs LM, Aronson S, Mou TCM, Pereira EFR, Thompson SM, Gould TD (2025). Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model. Cell Reports. 44, 115743.
- Georgiou P, Postle AF, Mou TCM, Potter LE, An X, Zanos P, Patton MS, Pultorak KJ, Clark SM, Ngyuyen V, Powels CF, Prokai-Tatrai K, Kirmizis A, Merchenthaler I, Prokai L, McCarthy MM, Mathur BN, Gould TD (2025) Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain. Molecular Psychiatry. 30, 4445-4459.
- Medeiro GC, Demo I, Goes FS, Zarate CA Jr, Gould TD (2024) Personalized use of ketamine and esketamine for treatment-resistant depression. Translational Psychiatry. 14, 481.
- Georgiou P, Zanos P, Mu TM, Gerhard DM, Highland JN, Jenne CE, Stewart BW, Pultorak K, Loesch D, Yuan P, Clark SM, Tonelli LH, Moaddel R, Zarate CA, Duman RS, Thompson SM, Gould TD (2022) Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nature Neuroscience.25, 1191-1200.
- Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA, Gould TD (2019) (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 116, 6441-6450.
- Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KSS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr., Gould TD (2016) NMDAR-independent antidepressant actions of ketamine metabolites. Nature. 533, 481-486.
