Faculty Member Profiles

Simon Akerman, Ph.D.

Associate Professor, Department of Neural and Pain Sciences
SCHOOL OF DENTISTRY

Research Interests

• Pathophysiology of primary headaches inc.
• Migraine
• Cluster Headache
• Animal models of primary headaches
• TMDs

Research Approaches

• Physiological methods in rodents
• In vivo Electrophysiology
• Laser Doppler Flowmetry
• Video Imaging
• Pain behaviors

Publications

1. S Akerman, B Simon and M Romero-Reyes (2017) Vagus nerve stimulation suppresses acute noxious activation of trigeminocervical neurons in animal models of primary headache. Neurobiol Dis. 102:96-104.
2. AP Andreou, PR Holland, S Akerman, O Summ, J Frederik, PJ Goadsby (2016) Transcranial Magnetic Stimulation and Potential Cortical and Trigeminothalamic Mechanisms in Migraine. Brain. 139:2002-2014.
3. S Akerman and PJ Goadsby (2015) Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine. Sci Trans Med. 7:308ra157.
4. M Romero-Reyes, V Pardi and S Akerman (2015) A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: role of CGRP in orofacial pain. Exp Neurol. 271:95-103.
5. S Akerman, PR Holland, MP Lasalandra and PJ Goadsby (2013) Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and 'triptan' receptors: implications in migraine. J Neurosci. 33:14869-14877.

View Simon Akerman's Faculty Profile