Steven M. Jay, PhD
Associate Professor in the Fischell Department of Bioengineering
A. James Clark School of Engineering
University of Maryland, College Park
Genetically-Programmed High-Yield Biomanufacturing of Probiotic Bacterial Extracellular Vesicles
This project will run from February 2025 to November 2025.
Co-Investigator
Jean-Pierre Raufman, MD
Moses Paulson, MD and Helen Golden Paulson Chair of the Division of Gastroenterology and Hepatology
University of Maryland School of Medicine
Site Miner
Robert van den Berg, PhD, MBA
Bio
Steven Jay’s lab aims to uncover new biological insights towards the design and development of novel biotherapeutics (aka biopharmaceuticals), including proteins, extracellular vesicles (exosomes) and others. The team also strives to develop new approaches to drug delivery and biomanufacturing using fundamental tools from both engineering and biology. Employing techniques in molecular biology, protein design and engineering, biomaterials and nanotechnology, they are primarily interested in developing new biotechnologies to address clinical needs in wound repair, cardiovascular disease, cancer, brain and spinal cord injuries, neurological diseases, osteoarthritis, and sepsis, among others. Overarching goals of the lab include developing therapeutics towards clinical translation and endowing trainees with the skills and knowledge necessary to become leaders in the biotechnology and pharmaceutical industries.