Paul Buehler, PharmD, PhD
Professor of Pathology
University of Maryland School of Medicine
A Fiberoptic catheter to measure O2 saturation
Reliable measures of arterial blood are essential for ill patients. The Buehler team is developing a catheter combining blood pressure sensors and pulse oximetry, in a way that delivers high accuracy for all patients, even those with pigmented skin.
For more information about this technology, please contact the UM Ventures, Baltimore team.
Bio
Dr. Buehler is a pharmacologist and toxicologist who utilizes both applied and mechanistic approaches to understand red blood cell hemolysis and the downstream effects extracellular hemoglobin, heme and iron toxicity. His work focuses on genetic/acquired anemias as well as toxin and mechanical device induced hemolysis to characterize the genomic and proteomic changes in tissue that preempt or coincide with pathology. This work has led to significant discoveries related to toxicant induced red blood cell damage following intravenous abuse of Opana ER. This collaborative work with FDA has contributed to the recall of the deterrent formulated opiate, Opana ER (Oxymorphone HCl extended release) after a shift toward greater intravenous abuse and subsequently increased clinical cases of thrombotic microangiopathy and hemolytic uremic syndrome.