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Bret A. Hassel, PhD
Bret Hassel received his BS from the University of Miami and his PhD from the Johns Hopkins University in 1989.
Following postdoctoral fellowships at the Uniformed Services University of the Health Sciences and the Cleveland Clinic Foundation, Hassel joined the faculty of the Department of Microbiology and Immunology at the University of Maryland School of Medicine in 1995.
Hassel is a member of the Tumor Immunology and Immunotherapy Program within the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) Program in Oncology, and is an associate professor of microbiology and immunology. Hassel's research focuses on the endoribonuclease RNase-L, a component of the innate immune response that mediates tumor suppressor activities. His studies described below have revealed novel roles for RNase-L in which it acts to attenuate inflammatory and proliferative responses thereby contributing to tumor suppressor and host defense activities. With the goal of developing RNase-L-targeted agents for diagnostic and therapeutic applications in cancer and immune disorders, Dr. Hassel actively collaborates with basic and clinical UMGCC investigators.