Clinical Research Currently Recruiting

Research continues on many fronts to better understand the causes of various, and often overlapping, pain conditions. It is with greater understanding that we expect to identify alternative treatment approaches that improve the lives of people suffering with unremitting pain. Currently, several research studies are being conducted at CACPR.

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Facial, Jaw, and Headache Pain

Chronic orofacial pain represents an economic burden in the United States and worldwide affecting 5 percent to 10 percent of the population. We have developed a novel and comprehensive genetic, behavioral, and imaging approach to study the role of genetic variations on pain mechanisms in healthy participants as well as participants with facial, jaw, and headache pain.

Who is eligible to participate?

You may qualify if:

  • You are 18 to 65 years of age
  • You speak and understand English
  • You are either in good health or you have had headaches, facial pain, and/or jaw pain recently

What would I do as a study participant?

This research study:

  • Requires one screening visit for ensuring eligibility
  • Requires one experimental study session lasting no more than four hours

Compensation for all sessions and parking vouchers are provided. If you are interested, please email us at or call 410-706-5975


"Enrollment is temporarily closed" - Burning mouth syndrome: central nervous system mechanisms

Burning mouth syndrome (BMS) is an orofacial chronic pain disorder affecting approximately 2 to 3 percent of the population. It is associated with burning pain of the oral mucosa, particularly the tongue, hard palate, and lips. The disease is thought to have multifactorial influences, including those of small fiber pathology, sex hormone levels, anxiety, and stress. The current study will examine multiple potential CNS abnormalities that could explain the symptomatology of BMS.

Who is eligible to participate?

Enrollment is temporarily closed.

This study seeks postmenopausal women, aged 40 to 65. We also seek healthy women of the same age range who have never had BMS or any other chronic pain condition.

What would I do as a study participant?

Participants will undergo testing for two days, which will include electroencephalography (EEG), magnetic resonance imaging (MRI), and quantitative sensory testing (QST). For more information, contact Shariq Khan or Mariya Prokhorenko, or call 410-706-4049.


"Enrollment is permanently closed" - Episodic migraine: a nonpharmacological clinical trial

Migraine is a common, debilitating condition, and current migraine therapies are often insufficient. In this clinical trial, teams at the University of Maryland and Johns Hopkins University investigate two interventions that could reduce migraine symptoms.

Who is eligible to participate?

Enrollment is permanently closed.

This study seeks men and women who have been diagnosed with migraine and have fewer than 15 headache days per month. We also seek healthy subjects who have never suffered from migraines or any other chronic pain condition.

What would I do as a study participant?

The study examines how brain structure and function change over time and involves three different MRI sessions. For more information, visit, email Alexandra Kearson or call 410-550-9056.