Ronald Dubner, DDS, PhD


Ronald Dubner, DDS, PhD

Professor, Department of Neural and Pain Sciences


Research interests

Descending brain stem modulation of persistent pain and spinal cord neuronal plasticity

Neural and glial interactions

Mechanisms of persistent orofacial pain

Research approaches

molecular, neurochemical and physiological changes in the peripheral and central nervous system following tissue and nerve injury and the development of new pharmacological strategies for controlling acute and persistent pain.


ORCID ID: 0000-0003-2027-2831


  1. Chai B, Guo W, Wei F, Dubner R, Ren K 2012 Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury. Mol. Pain 8:78.
  2. Okubo M, Castro A, Guo W, Zou S, Ren K, Wei, F Keller A, Dubner R  2013  Transition to persistent orofacial pain after nerve injury depends on supraspinal serotonin mechanisms. J. Neuroscience 33: 5152-5161.
  3. Kim YS, Chu Y, Han L, Li M, Li Z, Lavinka PC, Sun S, Tang Z, Park K, Caterina MJ, Ren K, Dubner R, Wei F, Dong X 2013 Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain. Neuron. 19;81(4):873-87. doi: 10.1016/j.neuron.2013.12.011. Epub 2014 Jan 23.
  4. Slade GD, Fillingim RB, Sanders AE, Bair E, Greenspan JD, Ohrbach R, Dubner R, Diatchenko L, Smith SB, Knott C, Maixner W. 2013 Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions. J Pain. (12 Suppl):T116-24. doi: 10.1016/j.jpain.2013.09.010.
  5. Guo W, Miyoshi K, Dubner R, Gu M, Li M, Liu J, Yang J, Zou S, Ren K, Noguchi K, Wei F.  2014 Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Mol Pain. 9;10:35. doi: 10.1186/1744-8069-10-35. PMID:24913307; PMC4067691.