Titles

Assistant Professor of Practice, Sciences, and Health Outcomes Research

Director, MS in Pharmacometrics

School Affiliation

School of Pharmacy

Specialties

• Pharmacometrics
• Bayesian Applications in Drug Development
• Innovative Clinical Trial Designs

About

706-7842 mgopalakrishnan@rx.umaryland.edu

Dr. Gopalakrishnan earned an MS and PhD in statistics at the University of Maryland, Baltimore County. She holds a BPharmacy and a MPharm from Birla Institute of Technology & Science, Pilani, Rajasthan, India Her research focuses on pharmacometrics, precision therapeutics, predictive analytics, real world data, and drug development. She utilizes fundamental principles of clinical pharmacology (pharmacokinetics (PK)/pharmacodynamics (PD)), advanced statistical (frequentist and Bayesian) methods (modeling and simulation), and artificial intelligence (AI/ML) techniques to improve clinical and therapeutic outcomes for patients, especially vulnerable populations. Dr. Gopalakrishnan's lab has designed and conducted prospective, real-world clinical pharmacokinetic trials for anti-epileptics/anti-microbials in continuous renal replacement therapy patients with the goal to develop individualized antiepileptic regimens. She has worked on using real world data (electronic health records, prospective pragmatic clinical trials) in the areas of neonatal opioid withdrawal syndrome, and anti-coagulants in pediatrics to inform optimal dosing. She is involved in design and analysis of pharmacokinetic-pharmacodynamic studies for nutritional supplements and low-calorie artificial sweeteners in pregnant and postpartum women to answer questions on optimal dosing of the nutritional supplements. Her additional areas of research include models for disease progression (e.g: schizophrenia, binge-eating disorders), AI/ML approaches to identify biomarker-endpoint relationship in medical countermeasure development, innovative quantitative methods for trial design/analysis, and predictive analytics in transfusion decision making. Her lab works collaboratively with academic medical institutions across the country.

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Tagged: The Future of Health Care   Research and Innovation  

This information was last updated May 17, 2023.