My research focuses on how the synaptic proteins acetylcholinesterase (AChE) and acetylcholine receptor (AChR) are targeted to their subcellular and extracellular sites and what intracellular components are important in the regulation of their expression. The goals of the research are (1) to William Randall, cotinued determine how innervation controls the synthesis and expression of AChE and AChR at the cholingeric synapse, (2) to identify which steps in gene expression are important in controlling synaptic AChE expression during developmental maturation of muscle and (3) to examine what role the transcripts encoding specific forms of AChE play in the expression and final targeting to their cellular and extracellular sites.
Randall, W.R., "Cellular expression of cloned hydrophilic murine acetylcholinesterase: evidence of palmitoylated membrane-bound forms", J. Biol. Chem. 269:12367-12374, 1994.