Local Signals and Macromolecular Architecture in Heart

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Heart Failure

Overview 

Projects
T. B. Rogers
R. J. Bloch
W. J. Lederer

Cores
Molecular Genetics
Cell Biology 

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Project 3: Lederer

 Subcellular Organization and Ca2+ Signaling
in Heart Failure

Publications

Mohler, P.J. , Schott,J.-J., Gramolini, A.O., Dilly, K.W., Guatimosim, S., duBell, W.H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M.E., Rogers, T.B., Lederer, W.J., Escande, D., Le Marec, H., Bennett, V. (2003) Ankryin-B Mutation Causes Type 4 Long QT Cardiac Arrhythmia and Sudden Cardiac Death, Nature, 421, 634-639.

duBell, W.H., Gigena, M., Guatimosim, S., Long, X., Lederer, W.J., and Rogers, T.B (2002) Effects of the PP1/PP2A Inhibitor calyculin A on the E-C coupling cascade in murine ventricular myocytes, Am.J.Physiol., in press.

duBell, W.H., Gaa, S.T., Lederer, W.J., and Rogers, T.B. (1998) Independent Inhibition of Calcineurin and K+ Currents by the Immunosupressant FK-506 in Rat Ventricle Am. J. Physiol., 275, H2041-H2052.

duBell, W.H., Lederer, W.J., and Rogers, T.B. (2000) The K+ Currents Responsible for Repolarization in Mouse Ventricle and Their Modulation by FK506 and Rapamycin Am. J. Physiol. 278, H886-H897

Kohout, T.A., O'Brian, J.L., Gaa, S.T., Lederer, W.J. and Rogers, T.B. (1996) A Novel Adenovirus Component System that Transfects Cultured Cardiac Cells with High Efficiency. Circ. Res. 78, 971-977.

duBell, W.H., Lederer, W.J., and Rogers, T.B. (1996) Dynamic Modulation of Cardiac Excitation-Contraction Coupling by Protein Phosphatases. J. Physiol. 493, 793-800.

duBell, W.H., Wright, P.A., Lederer, W.J., and Rogers, T.B. (1997) FK506 Alters Excitation-Contraction Coupling by Inhibition of Outward K Currents in Rat Ventricular Myocytes. J. Physiol. 501, 509-516.

Lokuta, A.J., Rogers, T.B., Lederer, W.J. and Valdivia, H.H. (1995) Modulation of cardiac muscle ryanodine receptors by a phosphorylation/dephosphorylation mechanism. J. Physiol., 487,609-622

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Lederer
W. J. Lederer, MD, PhD, Director
, Medical Biotechnology Center, University of Maryland Biotechnology Institute

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Program Project Grant in Heart Failure

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