Cardiomyopathy induced by JNK activation

Cardiomyopathy induced by JNK activation in vivo. Development of cardiomyopathy upon JNK activation. Isolated hearts from tamoxifen treated double transgenic animals at different time points after tamoxifen treatment. The blue line represents survival curve of animals after gene-induction, showing nearly 40% sudden death at early stage and less than 3 months to maximum life span.