Local Signals and Macromolecular Architecture in Heart

PPG Home

Heart Failure

Overview 

Projects
T. B. Rogers
R. J. Bloch
W. J. Lederer

Cores
Molecular Genetics
Cell Biology 

Positions
Graduate Students
Postdoctoral Fellows
Junior Faculty  

PPG Members
(login required)

Molecular Genetics Core

William R. Randall, Ph.D., Core Leader

Produces recombinant adenovirus expressing cardiac proteins to serve the specific aims of the three projects of the PPG.

The principal goal of the Molecular Genetics Core is to coordinate, produce, and provide recombinant adenovirus expressing cardiac proteins to serve the specific aims of the three projects of this PPG. Although the emphasis of this core is to maximize the output of adenoviral constructs for the projects, it is also responsible for performing several cloning procedures, when needed, to create the adenovirus constructs. These include creating fusion proteins containing autofluorescent and epitope tags, site directed mutagenesis of cardiac proteins, and producing truncated and chimeric proteins from supplied cDNAs as required by the three projects.

The Molecular Genetics Core has produced recombinant adenovirus preparations that express a wide variety of proteins that range from cytoskeletal proteins to kinase and phosphatase subunits expressed in cardiomyocytes. Many of these are being used in two or more projects.

 

 

chemistry

Approaches and Results

Publications

Related Links

University of Maryland BaltimoreUniversity of Maryland School of MedicineMedical Biotechnology CenterSearch


Program Project Grant in Heart Failure

Room 215 Biomedical Research Facility | 108 N. Greene Street | Baltimore, MD 21201
© 2004 | All Rights Reserved | Contact Jane Bacon

School of Medicine