Local Signals and Macromolecular Architecture in Heart

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Sumbilla, C., Lakowicz, J.R., Fluorescence studies of red blood cell membranes from individuals with Huntington's disease, Journal of Neurochemistry, 38, 1699, (1982).

Sumbilla, C.M., Zielke, H.R., Krause, B.L., Ozand, P.T., Activity of gluconeogenic enzymes in fibroblasts from infants dying of the sudden infant death syndrome (SIDS), European Journal of Pediatrics, 140, 276, (1983).

Sumbilla, C., Waechter, C.J., Properties of brain dolichol kinase activity solubilized with a Zwitterionic Detergent, Archives of Biochemistry and Biophysics, 238, 75 (1985).

Sumbilla, C., Inesi, G., Rapid filtration measurements of Ca2+ release from cisternal sarcoplasmic reticulum vesicles, FEBS Letters, 210, #1, 31 (1987) .

Chu, A., Sumbilla, C., Jay, S.D., Campbell, K.P., Inesi, G., Specific association of calmodulin-dependent protein kinase and related substrates with the junctional sarcoplasmic reticulum of skeletal muscle, Biochemistry, 29, 5899, (1990).

Inesi,G., Sumbilla, C., and Kirtley, M.E.,  Relationships of molecular structure and function in the Ca2+ transport ATPase. Physiological Reviews, Vol. 7, No. 3, (1990).

Sumbilla,C., Cantilina,T., Collins,J.H., Malak,H., Lakowicz,J.R., Inesi,G., Structural Perturbation of the Transmembrane Region Interferes with Calcium Binding by the Ca2+Transport ATPase.  Journal of Biol. Chem. ,266, 12682 ,(1991).

Sumbilla,C., Lu, L., Lewis, D., Inesi, G., Ishii, T., Takeyasu, K., Feng, Y. and Fambrough, D., Ca2+-Dependent and Thapsigargin-inhibited Phosphorylation of Na+,K+-ATPase Catalytic Domain Following Chimeric Recombination with Ca2+-ATPase. Journal of Biol. Chem.,268, 21185-21192,(1993).

Zhang, Z., Sumbilla, C., Lewis, D. Summers, S. , Klein M. and Inesi, G., Mutational Analysis of the Peptide Segment Linking Phosphorylation and Ca2+ Binding Domains in the Sarcoplasmic Reticulum Ca2+ ATPase.  Journal of Biol. Chem., 270, 16283-16290,(1995)

Chen, L., Sumbilla, C., Lewis, D. Zhong, L., Strock, C. Kirtley, M. and Inesi, G., Short and Long Range Function of Amino Acids in the Transmembrane Region  of the Sarcoplasmic Reticulum  ATPase.  Journal of Biol. Chem., 271, 10745-10752, (1995).

Garnett, C., Sumbilla, C., Fernandez-Belda, F. and Inesi, G. Energy Transduction and Kinetic Regulation by the Peptide Segment Connecting Phosphorylation and Cation Binding Domains in transport ATPases. Biochemistry ,35, 11019-11025, (1996).

Inesi, G., Lewis, D., Sumbilla, C., Nandi, A., Strock, C., Huff, K., Rogers, T. Johns, D.C., Kessler, P.D. and Ordahl, C.P. Cell-specific promoter in adenovirus vector for transgenic expression of SERCA1 ATPase in cardiac myocytes. American Journal of Physiology Cell Physiology  274 (43) C645-C653, (1998).

Strock, C.,  Cavagna, M., Peiffer, W., Sumbilla, C., Lewis, D. and Inesi, G. Direct Demonstration of Ca2+ Binding Defects in Sarco-Endoplasmic Reticulum Ca2+ATPase Mutants Overexpressed in COS-1 Cells Transfected with Adenovirus Vectors.  Journal of  Biological Chemistry,  273,115104 -15109, (1998).

Sumbilla, C.,  Cavagna, M.,  Zhong, L.,  Ma, H., Lewis, D., Farrance, I., and Inesi, G. Comparison of SERCA1 and SERCA2a Expressed in COS-1 Cells and Cardiac Myocytes. American J. Physiol. (Heart Circ. Physiol. ) , 277: H2831-H2391(1999).

 Inesi, G., Cavagna, M., O'Donnell, J.M., Sumbilla, C., Zhong, L., Ma, H., and Klein, M.G. "Adenovirus Mediated Gene Transfer of SERCA Isoforms." in Molecular Approaches to the Therapy of Heart Failure. Hasenfuss, G., ed., Springer-Steinkopff ,  pp. 77-88, (2000).

Cavagna, M., O’Donnell, M., Sumbilla ,C. , Inesi,G. and Klein, M.G.  Exogenous Ca2+-   ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes. Journal of Physiology. 528(1): 53-63 (2000).

O’Donnell, M., Sumbilla, C., Ma, H., Farrance, I., Cavagna, M., Klein, M.G. and Inesi, G. Tight Control of  Exogenous SERCA Expression is Required to Obtain Acceleration of Calcium Transients with Minimal Cytotoxic Effects in Cardiac Myocytes. Circulation Research. 88: 415-421 (2001).

Zhang, Z., Lewis, D., Sumbilla, C., Inesi, G. and Toyoshima,C.  The Role of  the M6-M7 Loop (L67) in Stabilization of the Phosphorylation  and Ca+2 Binding Domains of the Sarcoplasmic Reticulum Ca+2-ATPase. Journal of Biological Chemistry.  276: 15232-15239 (2001).

 Sumbilla, C., Lewis,D., Hammerschmidt,T. and Inesi, G.  The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum. Journal of Biological Chemistry. 277:13900 -13906 (2002).

Sumbilla, C., Ma, H., Seth, M. and Inesi, G.  Dependence of exogenous SERCA gene expression on Coxsackie adenovirus receptor levels in neonatal and adult cardiac myocytes.  Arch Biochem Biophys. 415: 178-183 (2003).

Ma, H. ,  Sumbilla, C.M.,  Farrance, I.,  Klein, M.G. and  Inesi ,G.  Cell specific expression of exogenous Ca2+ Transport ATPase (SERCA) in cardiac myocytes. Am J Physiol Cell Physiol 286:C554-C564 (2004).

 Seth,M., Sumbilla,C., Mullen,S., Lewis,D., Klein,MG., Hussain,A., Soboloff,J., Gill,DL and Inesi,G. Ca2+ ATPase (SERCA) Gene Silencing and Remodeling of the Ca2+ Signaling Mechanism in Cardiac Myocytes. Proc. Nat. Acad Sci. USA 101: 16683-16688 (2004).

Weisser-Thomas J., Dieterich, E.,Jennsen,P.M..,Schmidt-Schweda, S., Maier, L.S., Sumbilla,C., and Pieske,B. Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes. J. Pharmacol. Toxicol Methods 51: 91-103 (2005).

Carlota Sumbilla, PhD
Assistant Professor,
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine

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