Chemical Information for Carcinogens, Reproductive Toxins and Chemicals with High Acute Toxicity

This website provides information on carcinogens, reproductive toxins, and chemicals that have a high level of acute toxicity. Addition resources on the health effects of chemicals also are provided. 

CARCINOGEN

Below is the definition the Occupational Safety and Health Administration (OSHA) provides for carcinogen in its Use of Hazardous Chemical’s in the Laboratory Standard. Also provided are the web links to the agencies OSHA references for carcinogens. 

OSHA Definition: Select carcinogen means any substance that meets one of the following criteria:

(i) It is regulated by OSHA as a carcinogen; or

(ii) It is listed under the category, "known to be carcinogens," in the Annual Report on Carcinogens published by the National Toxicology Program (NTP)(latest edition); or

(iii) It is listed under Group 1 ("carcinogenic to humans") by the International Agency for Research on Cancer Monographs (IARC)(latest editions); or

(iv) It is listed in either Group 2A or 2B by IARC or under the category "reasonably anticipated to be carcinogens" by NTP, and causes statistically significant tumor incidence in experimental animals in accordance with any of the following criteria:

(A) After inhalation exposure of 6-7 hours per day, 5 days per week, for a significant portion of a lifetime to dosages of less than 10 mg/m(3);

(B) After repeated skin application of less than 300 (mg/kg of body weight) per week; or

(C) After oral dosages of less than 50 mg/kg of body weight per day.

Annual Report on Carcinogens published by the National Toxicology Program

Know to be Human Carcinogens: http://ntp.niehs.nih.gov/pubhealth/roc/index.html

Reasonable Anticipated Human Carcinogens: http://ntp.niehs.nih.gov/pubhealth/roc/index.html

International Agency for research on Cancer Monographs for Carcinogens

Group 1: Carcinogenic to humans

Group 2A: Probably carcinogenic to humans

Group 2B: Possibly carcinogenic to humans:

http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php

REPRODUCTIVE TOXINS

Below is the definition OSHA provides for reproductive toxin in its Use of Hazardous Chemicals in the Laboratory Standard.

OSHA Definition: Reproductive toxin means chemicals that affect the reproductive capabilities including chromosomal damage (mutations) and effects on fetuses (teratogenesis).
 
Examples include:   
Arsenic and certain arsenic compounds
Benzene
5-Bromo-2-Deoxyuridine (BrdU)
Cadmium and certain cadmium compounds
Carbon disulfide
Ethylene glycol monomethyl and ethyl ethers
Ethylene oxide
Lead compounds
Mercury compounds
Nitrous Oxide
Toluene
Vinyl chloride
           
HIGH LEVEL OF ACUTE TOXICITY

Below are the definition and list of high level of acute toxicity provided in the 2011 printing of Prudent Practices in the Laboratory and a list of examples they provide.

Compounds with a high level of acute toxicity — Table 1 lists respective LD50 and LC50 levels for these compounds.

High Level of Acute Toxicity

Oral LD50 (Rats, per kg)

Skin Contact LD50 (Rabbits, per kg)

Inhalation LC50 (Rats, ppm for 1 hour)

Inhalation LC50 (Rats, mg/m3 for 1 hour)

< 50 mg

< 200 mg

< 200

< 2000

 
Examples include:

Acrolein
Arsine
Chlorine
Diazomethane
Diborane (gas)
Dimethyl Mercury
Hydrogen cyanide
Hydrogen fluoride
Methyl fluorosulfonate
Nickel carbonyl
Nitrogen dioxide
Osmium tetroxide
Ozone
Phosgene
Sodium azide
Sodium cyanide (and other cyanide salts)

ADDITIONAL INFORMATION

Additional information on the hazardous properties of chemicals can be found on their Material Safety Data Sheet(s) or at the following website:

TOXNET: http://toxnet.nlm.nih.gov/